groES Antibody

1. Single-molecule observation of protein folding in symmetric GroEL-(GroES)2 complexes PMID: 23048033
2. Studies indicate that the amount of GroEL and GroES in an E. coli cell under normal conditions is sufficient to assist in the folding of no more than 5% of the proteins within the cell. PMID: 22177460
3. substrate folding activity of a single ring GroEL variant is stimulated by modulating the cochaperonin GroES PMID: 21757689
4. unfolded GroES has covalent structural changes that lead to amyloid fibril formation detected by NMR PMID: 21507961
5. The association of ATP and GroES to a polypeptide-bound ring of GroEL encapsulates the folding proteins in the central cavity of that ring (cis ring) and allows it to fold in a protected environment where the risk of aggregation is reduced. PMID: 20006619
6. structural analysis of GroEL and its binding to GroES PMID: 15475965
7. the two stages of GroES fibril formation prefer different molecular states of the same protein PMID: 16054644
8. a shift in orientation of GroEL apical domains between the apo-protein and stable GroEL.GroES complexes is highly ordered, and transient conformational intermediates permit the association of GroES before the displacement of bound polypeptide PMID: 16684774
9. GroEL holds the nascent chain on the ribosome in a polypeptide length-dependent manner and post-translationally encapsulates the polypeptide using the GroES cap to accomplish the chaperonin-mediated folding process. PMID: 16754671
10. Coexpression of GroEL and GroES enhanced the growth rate of aconitase producing cells by 30%. PMID: 16822698
11. F170L su substitution has a decreased requirement for the chaperones GroEL and GroES as a result of restoring the temperature-sensitive-folding coat proteins to a wild type-like state. PMID: 17441504
12. Data show that structure-forming characteristics of GroES appear to be conserved through the backbone reversal process, although the differential conformational behavior upon heating also indicates differences. PMID: 18359305
13. The GroEL/GroES compartment is essential for protein folding in vivo. PMID: 18418386
14. there is an an intermediate GroEL/substrate/GroES complex in which the substrate and GroES bind to GroEL by sharing seven common binding sites PMID: 18430731

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KEGG: ecj:JW4102

STRING: 316385.ECDH10B_4335