Mi-2 Antibody

Datasheet

Code	CSB-PA528539XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Mi-2 Polyclonal antibody

Uniprot No.

O97159

Target Names

Mi-2

Alternative Names

Mi-2 antibody; CG8103Chromodomain-helicase-DNA-binding protein Mi-2 homolog antibody; EC 3.6.4.12 antibody; ATP-dependent helicase Mi-2 antibody; dMi-2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Mi-2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Helicase which acts in nucleosome-remodeling by catalyzing ATP-dependent nucleosome mobilization. Involved in regulating transcription. Plays a vital role in development. Binds to a portion of Hunchback (HB) protein that is critical for repression of bithorax complex (BXC) genes. May also function in polycomb group (PcG) repression of Hox genes. May also act as part of the nucleosome remodeling and deacetylase complex (the NuRD complex) which participates in the remodeling of chromatin by deacetylating histones.

Gene References into Functions

Genetic experiments in Drosophila demonstrate that expression of cancer-derived dMi-2 mutants misregulates differentiation of epithelial wing structures and produces phenotypes that correlate with their nucleosome remodelling properties. PMID: 29844320
EcR and dMi-2 form a complex that is devoid of Ultraspiracle. Unexpectedly, EcR contacts the dMi-2 ATPase domain and increases the efficiency of dMi-2-mediated nucleosome remodelling PMID: 28378812
dMi-2 is an important regulator of both chromosome condensation and cohesin binding in interphase cells. PMID: 22912596
The results suggest that dMi-2 distribution over active heat shock genes are determined by transcriptional activity. PMID: 22362736
chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization PMID: 12006495
Results suggest that Drosophila Mi-2/NuRD complex functions in neuronal differentiation through the repression of proneural gene expression by chromatin remodeling and histone deacetylation. PMID: 16961588

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Subcellular Location

Nucleus. Chromosome.

Protein Families

SNF2/RAD54 helicase family

Database Links

KEGG: dme:Dmel_CG8103

STRING: 7227.FBpp0099808

UniGene: Dm.28317

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Mi-2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background