chn Antibody

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Code	CSB-PA773570XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) chn Polyclonal antibody

Uniprot No.

Q7YU81

Target Names

chn

Alternative Names

chn antibody; CG11798Protein charlatan antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) chn protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Probable transcription factor involved in the development of the adult pattern of macrochaetae. Required for accumulation of achaete (ac) and scute (sc) in proneural clusters. Probably acts by binding to the proneural cluster-specific enhancers of the ac/sc complex and increasing enhancer efficiency, thereby acting as a stimulator of ac/sc expression in proneural clusters. Also required for correct development of the embryonic/larval peripheral nervous system (PNS).

Gene References into Functions

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila. PMID: 24961799
Chn is a dual functional regulator of transcription. PMID: 21762412
mutation decreases the accumulation of Sc in proneural clusters, affecting notum macrochaetae, overexpression enhances ac/sc PMID: 15703278
under EGF signaling, double negative regulation mediated by the Ebi/SMRTER corepressor complex and an NRSF/REST-like factor, Chn, maintains inductive activity in developing photoreceptor cells by promoting Dl expression PMID: 16763555

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in the PNS and CNS. In early blastoderm stages, it is ubiquitously expressed, then, before stage 5, it disappears from the poles of the embryo and faint stripes are visible. At stage 5, it also accumulates in the dorsal region, cephalic furrow e

Database Links

KEGG: dme:Dmel_CG11798

STRING: 7227.FBpp0293744

UniGene: Dm.11696

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chn Antibody

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