Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CLV2 Polyclonal antibody

Uniprot No.

O80809

Target Names

CLV2

Alternative Names

CLV2 antibody; RLP10 antibody; At1g65380 antibody; T8F5.16Receptor-like protein CLAVATA2 antibody; Receptor-like protein 10 antibody; AtRLP10 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana CLV2 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Required for the sensing of the root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also CRN and leads to root growth regulation, mostly in the phloem and protophloem. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection. CLE14 perception by CLV2/CRN complex triggers root meristem differentiation.

Gene References into Functions

study reports that the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) are necessary to fully sense root-active CLE peptides PMID: 28607033
CLV1 and CLV2, two receptors involved in CLV3 perception during plant development, contribute to bacterial wilt through a signalling pathway involving the miR169/NF-YA module. PMID: 26990325
Gene NANA regulates cell proliferation in Arabidopsis thaliana shoot apical meristem without interaction with CLV2. PMID: 25752149
Over-expression of CLV2 in wild-type plants unexpectedly resulted in a multi-carpel phenotype, mimicking the clv2 mutant, which suggests a co-suppression effect on the endogenous CLV2. PMID: 20961653
Data report detection of distinct CLV2-CRN heteromultimeric and CLV1-BAM multimeric complexes in transient expression in tobacco and in Arabidopsis meristems. PMID: 20626648
tested the hypothesis by replacing these cysteines with alanines and showed that depletions of one or both of the cysteine pairs do not hamper the function of CLV2 in SAM maintenance PMID: 20738721
Studies evaluating the functional specificity of of CLV2 and its related proteins are reported. PMID: 19897604

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Families

RLP family

Tissue Specificity

Mostly expressed in apices (e.g. shoot apical meristem and flower buds), and, to a lower extent, in flowers, leaves, seedlings and siliques. Also expressed in the inner tissues of the proximal root meristem. Expressed throughout the vascular cylinder of r

Database Links

KEGG: ath:AT1G65380

STRING: 3702.AT1G65380.1

UniGene: At.17109

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CLV2 Antibody

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