CBL1 Antibody

Code CSB-PA529313XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CBL1 Polyclonal antibody
Uniprot No.
Target Names
CBL1
Alternative Names
CBL1 antibody; SCABP5 antibody; At4g17615 antibody; dl4845w antibody; FCAALL.122Calcineurin B-like protein 1 antibody; SOS3-like calcium-binding protein 5 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana CBL1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses. May function as a positive regulator of salt and drought responses and as a negative regulator of cold response. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in response to glucose and gibberellin during germination and seedling development and in response to cold stress. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF.
Gene References into Functions
  1. These analyses reveal not only the fundamental role of CBL1 in the adjustment of central transcriptomic networks involved in maintaining adequate physiological homeostasis processes, but also that a high shoot-root dynamics is required for the proper deployment of Al resistance responses in the root. PMID: 28150888
  2. a crucial function for CBL1 and CBL9 in pollen germination and tube growth PMID: 23741064
  3. These results indicate a novel role for CBL1 in modulating responses to glucose and gibberellic acid signals. PMID: 23437128
  4. a novel general regulatory mechanism of CBL-CIPK complexes in that CBL phosphorylation at their flexible C terminus likely provokes conformational changes that enhance specificity and activity of CBL-CIPK complexes toward their target proteins PMID: 22253446
  5. Deletion of CBL1 may disturb the perception of calcium influx by cold stress and results in altered cold-induced signaling and adaption. PMID: 21600398
  6. The results of this study imply that plasma membrane-localized CBL1- and CBL9-CIPK23 complexes simultaneously regulate potassium transport processes in roots and in stomatal guard cells. PMID: 17922773
  7. Results show that a 12-amino acid peptide of CBL1 is sufficient to mediate dual lipid modification and to confer plasma membrane targeting. PMID: 18502848

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Subcellular Location
Cell membrane; Lipid-anchor. Note=The cell membrane localization is S-acylation dependent and is abolished by 2-bromopalmitate (2-BP) treatment.
Protein Families
Calcineurin regulatory subunit family
Tissue Specificity
Preferentially expressed in stems, roots and siliques. Coexpressed with CIPK15/PKS3 in guard cells. Co-localized with CIPK23 in root tips and vascular bundles in the stem and the leaf, as well as in guard cells.
Database Links

KEGG: ath:AT4G17615

STRING: 3702.AT4G17615.1

UniGene: At.11088

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