comm Antibody

1. PRRG4 could re-localize hRobo1 from the cell surface, suggesting that PRRG4 is a functional homologue of Comm. Comm is required for axon guidance and synapse formation in the fly, so PRRG4 could contribute to the autistic symptoms of WAGR by disturbing either of these processes in the developing human brain. PMID: 28859078
2. Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline. PMID: 12050141
3. the ability of Comm to localise intracellularly and hence regulate Robo surface levels requires sequences in both the N-terminal and transmembrane domains PMID: 14550530
4. These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout complex, critical for CNS and muscle development. PMID: 16531238
5. dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis. PMID: 17074801
6. findings show Fra mediates canonical chemoattraction in response to netrin & it functions independently of netrin to activate commissureless transcription, allowing attraction to be coupled to downregulation of repulsion in precrossing commissural axons PMID: 19325078

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KEGG: dme:Dmel_CG17943

STRING: 7227.FBpp0305237

UniGene: Dm.2546