cos Antibody

Code CSB-PA522704XA01DLU
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster (Fruit fly) cos Polyclonal antibody
Uniprot No. O16844
Target Names cos
Alternative Names cos antibody; cos2 antibody; costal-2 antibody; CG1708Kinesin-like protein costa antibody; Kinesin-like protein costal2 antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Immunogen Recombinant Drosophila melanogaster (Fruit fly) cos protein
Immunogen Species Drosophila melanogaster (Fruit fly)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation. May negatively regulate a hh-signaling pathway which functions in the intestinal immune response to bacterial uracil by activating the Duox-dependent production of reactive oxygen species (ROS).
Gene References into Functions
  1. Cos2 is sumoylated, which counteracts its inhibitory role on Smo accumulation in the wing. PMID: 28195188
  2. Data show Ci interaction with Su(fu) or Cos2 correlates with Su(fu)- or Cos2-mediated suppression of Ci activity PMID: 26271100
  3. The CORD region of Ci has a second function distinct from Cos2 binding that inhibits Ci processing. Cos2 binding to CORD relieves this inhibition. PMID: 20850429
  4. analysis of phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling PMID: 20435030
  5. Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner PMID: 14645371
  6. Cos2 recruits multiple kinases to efficiently phosphorylate Cubitus interruptus. PMID: 15691767
  7. Differential Hh target gene regulation can be accomplished by differential sensitivity of Cos2 and Su(Fu) to Hh. PMID: 15750186
  8. Cos2 motility plays an important role in its function, regulating the amounts and activity of Ci that ultimately interpret the level of Hh to which cells are exposed. PMID: 18691888

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Subcellular Location Cytoplasm, cytoskeleton.
Protein Families TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF27 subfamily
Database Links

KEGG: dme:Dmel_CG1708

STRING: 7227.FBpp0088087

UniGene: Dm.5775

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