CRBN Antibody

Code CSB-PA005944XA01CH
Product Type Polyclonal Antibody
Uniprot No. P0CF65
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Gallus gallus (Chicken) CRBN protein
Raised in Rabbit
Species Reactivity Gallus gallus (Chicken)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Protein cereblon CRBN
Immunogen Species Gallus gallus (Chicken)
Gene Names CRBN
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning.
Subcellular Location Cytoplasm, Nucleus
Protein Families CRBN family
Database Links

STRING: 9031.ENSGALP00000013451

UniGene: Gga.17910

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