Cereblon (CRBN) serves as the substrate receptor for the cullin 4-RING E3 ubiquitin ligase complex, CRL4CRBN. The CRBN gene comprises 11 exons, including two crucial binding domains essential for CRBN to function as the substrate receptor in the CRL4CRBN complex. CRBN is responsible for mediating the selective ubiquitination of proteins, leading to their subsequent degradation through the proteasome. Moreover, CRBN has been demonstrated to be indispensable for the functionality of thalidomide analogs, also known as immunomodulatory drugs (IMiDs). These drugs are used in the treatment of various hematological malignancies, such as multiple myeloma (MM), non-Hodgkin lymphoma (NHL), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). The significance of CRBN in these contexts highlights its crucial role in therapeutic approaches targeting blood-related malignancies.
Recombinant Human Protein cereblon (CRBN)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following CRBN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CRBN Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA005944GA01HU | CRBN Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA842761ESR1HU | CRBN Antibody |
Human, Mouse | ELISA, WB, IHC |
CSB-PA842761ESR2HU | CRBN Antibody |
Human, Mouse | ELISA, WB, IHC |
CRBN Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP710067RA CSB-EP710067RA CSB-BP710067RA CSB-MP710067RA CSB-EP710067RA-B |
Recombinant Rat Protein cereblon (Crbn) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF710067RA | Recombinant Rat Protein cereblon (Crbn) |
in vitro E.coli expression system |
CRBN Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP806030MO | Recombinant Mouse Protein cereblon (Crbn) |
Yeast |
CSB-EP806030MO CSB-BP806030MO CSB-MP806030MO CSB-EP806030MO-B |
Recombinant Mouse Protein cereblon (Crbn) |
E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRBN Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP842761HU1 CSB-MP842761HU1 CSB-EP842761HU1-B |
Recombinant Human Protein cereblon (CRBN), partial |
Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP842761HU | Recombinant Human Protein cereblon (CRBN) |
Baculovirus |
CSB-CF842761HUc7 | Recombinant Human Protein cereblon (CRBN) |
in vitro E.coli expression system |
CSB-CF842761HUa6 | Recombinant Human Protein cereblon (CRBN) |
in vitro E.coli expression system |
CSB-BP842761HUc7 | Recombinant Human Protein cereblon (CRBN) |
Baculovirus |
CSB-EP842761HU1 | Recombinant Human Protein cereblon (CRBN), partial |
E.coli |
CRBN Proteins for Homo sapiens(Human)
Code | Product Name | Source |
---|---|---|
CSB-CF842761HU | Recombinant Human Protein cereblon (CRBN) |
in vitro E.coli expression system |