CRBN Antibody

Code CSB-PA734655XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q68EH9
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CRBN protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Protein cereblon (zcrbn) crbn zgc:92404
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names crbn
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning.
Subcellular Location Cytoplasm, Nucleus
Protein Families CRBN family
Tissue Specificity Highly expressed in brain, head, vasculature otic vesicles and developing pectoral fins.
Database Links

KEGG: dre:445491

STRING: 7955.ENSDARP00000062723

UniGene: Dr.84847

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