Orai Antibody

Code CSB-PA890637XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Orai Polyclonal antibody
Uniprot No.
Target Names
Orai
Alternative Names
Orai; CRACM1; olf186-F; CG11430; Calcium release-activated calcium channel protein 1; Protein orai
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Orai protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import.
Gene References into Functions
  1. Ca2+ uptake in neurons with reduced SEPT7 requires Orai. PMID: 27225060
  2. These studies suggest that modulation of SOCE could serve as a novel mechanism for restoring dopamine levels in dopaminergic neurons. PMID: 26446229
  3. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. PMID: 23180775
  4. Orai1 is an essential component or regulator of the CRAC channel complex PMID: 16582901
  5. results demonstrate that the protein CRACM1 encoded by olf186-F is essential for store-operated Ca2+ influx via Ca2+ release-activated Ca2+ (CRAC) channels PMID: 16645049
  6. results indicate that Orai itself forms the Ca2+-selectivity filter of the CRAC channel PMID: 16921385
  7. The human ortholog of drosophila olf186-F interacts with STIM1 to regulate the amplitude of store-operated calcium entry. PMID: 16733527

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Orai family
Database Links

KEGG: dme:Dmel_CG11430

STRING: 7227.FBpp0113106

UniGene: Dm.7627

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