Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) CrebA Polyclonal antibody

Uniprot No.

P29747

Target Names

CrebA

Alternative Names

CrebA antibody; Bbbf2 antibody; CG7450Cyclic AMP response element-binding protein A antibody; cAMP response element-binding protein A antibody; dCREB-A antibody; Box B-binding factor 2 antibody; BBF-2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) CrebA protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'.

Gene References into Functions

Data suggest that CrebA is involved in regulation of infection tolerance in this species; expression of CrebA is regulated in the fat body upon infection; CrebA is required to survive infection and promotes tolerance of bacterial infection; CrebA deficiency leads to ER (endoplasmic reticulum) stress upon bacterial challenge. PMID: 29394281
CrebA deficiency leads to ER stress upon bacterial challenge PMID: 29394281
Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far. PMID: 21041443
direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1) PMID: 20065067
AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila PMID: 11976688
CrebA activity is linked to secretory function in multiple tissues PMID: 15901661
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity. PMID: 16009936
The CREB binding protein transcriptional cofactor is necessary and sufficient for down-regulation of DIAP1. PMID: 17591924

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Subcellular Location

Nucleus.

Protein Families

BZIP family

Tissue Specificity

In all cell types examined, including developing salivary gland in embryos and in adults, brain and optic lobe cell bodies, salivary gland, midgut epithelial cells of the cardia, female ovarian columnar follicle cells and male seminal vesicle, ejaculatory

Database Links

KEGG: dme:Dmel_CG7450

STRING: 7227.FBpp0089339

UniGene: Dm.6979

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CrebA Antibody

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