CRN Antibody

Datasheet

Code	CSB-PA888868XA01DOA
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Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CRN Polyclonal antibody

Uniprot No.

Q9LYU7

Target Names

CRN

Alternative Names

CRN antibody; SOL2 antibody; At5g13290 antibody; T31B5.110 antibody; Inactive leucine-rich repeat receptor-like protein kinase CORYNE antibody; Protein SUPPRESSOR OF OVEREXPRESSION OF LLP1 2 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana CRN protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that acts as a extracellular signals regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection. CLE14 perception by CLV2/CRN complex triggers root meristem differentiation. Required for the sensing of the root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also CLV2 and leads to root growth regulation, mostly in the phloem and protophloem. Promotes the accumulation of BAM3, especially at later stages of protophloem development.

Gene References into Functions

study reports that the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) are necessary to fully sense root-active CLE peptides; CRN stabilizes BAM3 expression and thus is required for BAM3-mediated CLE45 signaling. PMID: 28607033
Our results suggest a model in which CLV1/BAM1 and CLV2/CRN complexes act in separate, parallel pathways in shoot meristems, while the CLV1, CLV2, and CRN receptors function together in a linear pathway during fruit development. PMID: 21705761
A 12-mer random-peptide library was used to determine the specific amino acid sequences binding with the recombinant CRN molecule. PMID: 21214859
CRN contains features of a pseudokinase but lacks kinase activity PMID: 21398569
The results therefore imply that the CLE14/CLE20 peptides may act through the CLV2-CRN receptor kinase, and that their availabilities and/or abundances may be affected by cytokinin activity in planta. PMID: 20697738
This study suggested that the CLV3 signal is perceived by a tetrameric CLV2/CRN complex and a CLV1 homodimer that localize to the PM and can interact via CRN. PMID: 19933383
The novel receptor kinase CORYNE (CRN) and CLV2 act together, and in parallel with CLV1, to perceive the CLV3 signal. [CORYNE] [CRN] PMID: 18381924
SOL2, together with CLV2, plays an important role in the regulation of root meristem development through the CLE signaling pathway. [SOL2] PMID: 18854335

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Tissue Specificity

Present in roots, stems, leaves, inflorescence, flowers and siliques. Mostly expressed in shoot tips and, to a lesser extent, in young organs and roots. Also expressed in the inner tissues of the proximal root meristem. Expressed in the vascular cylinder

Database Links

KEGG: ath:AT5G13290

STRING: 3702.AT5G13290.2

UniGene: At.124

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CRN Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background