CRYGB Antibody

Code CSB-PA006018ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CRYGB Polyclonal antibody
Uniprot No. P07316
Target Names CRYGB
Alternative Names CRYGB antibody; CRYG2Gamma-crystallin B antibody; Gamma-B-crystallin antibody; Gamma-crystallin 1-2 antibody
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Homo sapiens CRYGB protein
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Applications : Immunofluorescence (IF)

Review: Representative fluorescence microscopy of Brn3a staining after 48 hours of cultivation with (B) or without (A) elevated hydrostatic pressure conditions (60 mm Hg), and with additional CRYAB (C).

By Anonymous

Target Background

Function
(From Uniprot)
Crystallins are the dominant structural components of the vertebrate eye lens.
Gene References into Functions
  1. Glycation of human gammaB-crystallin PMID: 28013006
  2. Allelic variant frequency of the gamma-crystallin promoter (g(-47) ->a) affects the level of its expression in platelets from cataract patients. PMID: 26552302
  3. Complex heterogeneous mutations in the gammaB crystallin gene have been described resulting in autosomal dominant congenital cataracts with three distinct phenotypes (lamellar, anterior polar, and complete cataracts) in the same family. PMID: 23288985
  4. -47C allele of rs2289917 in CRYGB showed the strongest association with cataract. PMID: 21941057
  5. The alphaB-crystallin oligomers formed long-lived stable complexes with their gammaD-crystallin substrates. PMID: 20621668
  6. In gammaD-crystallin, methylation is exclusively at Cys 110, whereas in gammaC- and gammaB-crystallins, the principal methylation site is Cys 22 with minor methylation at Cys 79 PMID: 12876325
  7. Possible sites for posttranslational modifications in gamma B crystallin. PMID: 14517968

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Involvement in disease Cataract 39, multiple types (CTRCT39)
Protein Families Beta/gamma-crystallin family
Database Links

HGNC: 2409

OMIM: 123670

KEGG: hsa:1419

STRING: 9606.ENSP00000260988

UniGene: Hs.248102

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