CSN8 Antibody

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Code	CSB-PA005796XA01DOA
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Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CSN8 Polyclonal antibody

Uniprot No.

P43255

Target Names

CSN8

Alternative Names

CSN8 antibody; COP9 antibody; FUS7 antibody; At4g14110 antibody; dl3095cCOP9 signalosome complex subunit 8 antibody; CSN complex subunit 8 antibody; Constitutive photomorphogenesis protein 9 antibody; Protein FUSCA 7 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana CSN8 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.

Gene References into Functions

while constitutively photomorphogenic9 (COP9) signalosome (CSN) mutants can complete embryogenesis and are able to germinate, they progressively lose meristem activity upon germination until they become unable to sustain growth PMID: 26277260
This review provides an overview of the highly complex regulation of CULLIN-RING E3 ubiquitin ligase activity by COP9 signalosome (CSN), and the many roles of the CSN in plant development and defense. PMID: 22325866
SMAP1 interacts with the COP9 signalosome. PMID: 22576848
COP9 has a role in ethylene signaling. PMID: 18429939

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

CSN8 family

Tissue Specificity

Ubiquitous.

Database Links

KEGG: ath:AT4G14110

STRING: 3702.AT4G14110.1

UniGene: At.4252

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Service

Phage Display Service

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Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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CSN8 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background