ct Antibody

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Code	CSB-PA320723XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) ct Polyclonal antibody

Uniprot No.

P10180

Target Names

Alternative Names

ct antibody; CG11387Homeobox protein cut antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) ct protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

Gene References into Functions

These analyses identified a host of putative Cut and/or Knot effector molecules, and a subset of these putative TF targets converge on modulating dendritic cytoskeletal architecture, which are grouped into three major phenotypic categories, based upon neuromorphometric analyses: complexity enhancer, complexity shifter, and complexity suppressor PMID: 29025914
Drosophila transcription factor Cut coordinately controls differentiation and repression of apoptosis via direct regulation of the pro-apoptotic gene PMID: 22438831
Turtle is downstream effector of Cut-mediated regulation of da neuron dendrite morphology. PMID: 21811639
Study of distant interactions of LCR from the locus CUT. PMID: 20886739
bft acts downstream of cut and tramtrack to implement correct bristle morphogenesis PMID: 12019237
Gene loci that interact with cut during Drosophila wing-margin development were identified. PMID: 15956666
Cut functions in regulating both cell differentiation and the cell cycle, and downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. PMID: 16141223
These results indicate that Cut functions as a transcriptional repressor of dPCNA gene by binding to the promoter region in the differentiated state PMID: 16629902
cut control the dendrite cytoskeleton and synergize to define final arbor shape. PMID: 18093520
cut protein acts in parallel to atonal, spalt-major and spalt-related transcription factors for differentiation of Johnston's organ of Drosophila antennae. PMID: 18820445

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Subcellular Location

Nucleus.

Protein Families

CUT homeobox family

Tissue Specificity

Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.

Database Links

KEGG: dme:Dmel_CG11387

STRING: 7227.FBpp0113105

UniGene: Dm.1827

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