Cytotoxin 2 Antibody

Code CSB-PA365557ZA01NFG
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Product Details

Full Product Name
Rabbit anti-Naja atra (Chinese cobra) Cytotoxin 2 Polyclonal antibody
Uniprot No.
Target Names
Cytotoxin 2
Alternative Names
Cytotoxin 2 (Cardiotoxin 1A) (Cardiotoxin 2) (CTX-2) (Cardiotoxin A2) (CTX A2) (Cardiotoxin II) (Cardiotoxin analog II)
Raised in
Rabbit
Species Reactivity
Naja atra
Immunogen
Recombinant Naja atra Cytotoxin 2 protein
Immunogen Species
Naja atra (Chinese cobra)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.
Subcellular Location
Secreted. Target cell membrane.
Protein Families
Snake three-finger toxin family, Short-chain subfamily, Type IA cytotoxin sub-subfamily
Tissue Specificity
Expressed by the venom gland.
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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