da Antibody

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Code	CSB-PA320868XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) da Polyclonal antibody

Uniprot No.

P11420

Target Names

Alternative Names

da antibody; CG5102Protein daughterless antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) da protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Daughterless/Achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.

Gene References into Functions

Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin. PMID: 27050508
We explain this paradox by demonstrating that Da induces the differentiation factor Prospero (Pros) whose asymmetric segregation is essential for differentiation in one of the two daughter cells. PMID: 24804774
we show that during the development of epithelial cells in the imaginal discs, the G2/M transition, and hence cell proliferation, is controlled by Emc via Da. In eukaryotic cells, the main activator of this transition is the Cdc25 phosphatase, string PMID: 24651265
Da transactivation domains play essential roles in neurogenesis and in E(spl)-mediated repression. PMID: 22949507
lilli contributes to ato auto-regulation in the morphogenetic furrow by first regulating the expression of da prior to ato. PMID: 22275119
coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila PMID: 12070099
Da confers neuronal identity to epithelial cells in the wing margin. PMID: 16554363
The expression of Dap was found to be controlled by the epidermal growth factor receptor signaling-regulated transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da). PMID: 17296729
Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis. PMID: 18407256
Study shows that the Drosophila class I factor Daughterless (Da) is upregulated by Hedgehog (Hh) and Decapentaplegic (Dpp) signalling during retinal neurogenesis. PMID: 18758436

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Subcellular Location

Nucleus.

Tissue Specificity

Ubiquitous.

Database Links

KEGG: dme:Dmel_CG5102

STRING: 7227.FBpp0304504

UniGene: Dm.388

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da Antibody

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