Dapk3 Antibody

Code CSB-PA006501XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Dapk3 Polyclonal antibody
Uniprot No.
Target Names
Dapk3
Alternative Names
Dapk3 antibody; Zipk antibody; Death-associated protein kinase 3 antibody; DAP kinase 3 antibody; EC 2.7.11.1 antibody; DAP-like kinase antibody; Dlk antibody; MYPT1 kinase antibody; ZIP-kinase antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Dapk3 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.
Gene References into Functions
  1. Estrogen promotes ethanol-evoked myocardial oxidative stress and left ventricular dysfunction via DAPK3/Akt/ERK activation in male rats. PMID: 26111663
  2. Data suggest that intestinal edema inhibits MLC phosphorylation by decreasing inhibitory phosphorylation of MYPT1 via decreased ROCK and ZIPK activities, resulting in more MLC phosphatase activity. PMID: 22235829
  3. ZIPK is involved in the regulation of smooth muscle contraction through direct phosphorylation of LC(20). PMID: 21880706
  4. ZIPK may act as a cardiac RLC kinase and thereby affect contractility. PMID: 20038585
  5. DAPK catalytic activity in the hippocampus increases during the recovery phase in an experimental rat model of brain hypoxic-ischemic injury. PMID: 12445468
  6. involved in the tumor necrosis factor molecular signaling pathways activated during seizure-induced neuronal death PMID: 12911633
  7. results demonstrate that DAPK is a S6 kinase and provide evidence for a novel role of DAPK in the regulation of translation PMID: 17087515
  8. Par-4 facilitates contraction by targeting ZIPK to the vicinity of its substrates, myosin light chain and MYPT, which are located on the actin filaments. PMID: 18505470
  9. Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. PMID: 19541925

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Subcellular Location
Nucleus. Nucleus, PML body. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center. Chromosome, centromere. Cytoplasm, cytoskeleton.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
Tissue Specificity
Ubiquitously expressed in all tissue types examined. High levels in brain, heart, lung and spleen, lower expression in kidney, liver, skeletal muscle and testis. Isoform 2 is expressed in the smooth muscle.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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