DAT Antibody

Datasheet

Code	CSB-PA695254XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) DAT Polyclonal antibody

Uniprot No.

Q7K4Y6

Target Names

DAT

Alternative Names

DAT antibody; fmn antibody; CG8380 antibody; Sodium-dependent dopamine transporter antibody; Protein fumin antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) DAT protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin. Plays a role in the regulation of the rest/activity cycle.

Gene References into Functions

When DAT, a member of the post-feeding reward system, is either overexpressed or reduced via mutation, Drosophila has increased sensitivity to amino acid starvation. PMID: 26909968
X-ray crystal structures of dopamine transporter (DAT) bound to its substrate dopamine, a substrate analogue 3,4-dichlorophenethylamine, the psychostimulants d-amphetamine and methamphetamine, or to cocaine and cocaine analogues PMID: 25970245
Phosphatidylinositol-4,5-Biphosphate regulates psychostimulant behaviors through its interaction with a membrane dopamine transporter. PMID: 24880859
the dopamine transporter X ray structure reveals the molecular basis for antidepressant action on sodium-coupled neurotransmitter symporters and elucidates critical elements of eukaryotic transporter structure and modulation by lipids PMID: 24037379
Description of the kinetics of endogenous and exogenous dopamine clearance by DAT, measured in a Drosophila larval CNS. PMID: 23600464
The disulfide bond between extracellular loop 2 cysteines is required for DAT biosynthesis and/or its delivery to the cell surface. PMID: 17131045

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family

Tissue Specificity

Expression is restricted to dopaminergic neurons in the central nervous system.

Database Links

KEGG: dme:Dmel_CG8380

STRING: 7227.FBpp0303037

UniGene: Dm.2848

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