DAT

DAT, the dopamine transporter, is a crucial transporter protein located on the presynaptic membrane of dopamine neurons. Structurally, it possesses a specific protein conformation that enables efficient reuptake of dopamine from the synaptic cleft back to the presynaptic membrane. Functionally, DAT maintains the stability of dopamine concentration in the synaptic cleft through active dopamine transport, thereby preserving the accuracy and efficiency of neural signal transmission. Additionally, DAT interacts with other neurotransmitter systems to jointly regulate neuronal excitability. Previous studies have shown that DAT interacts with certain kinases, phosphatases, and other transporters or receptors, collectively forming a complex signaling network.