daz-1 Antibody

Code CSB-PA631333XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans daz-1 Polyclonal antibody
Uniprot No.
Target Names
daz-1
Alternative Names
daz-1 antibody; F56D1.7DAZ protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans daz-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
RNA-binding protein that plays a central role in oogenesis, but not for spermatogenesis. Required for meiotic entry and germline differentiation, at the pachytene stage of meiosis I of female germline regardless of the sex of the soma. May act by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR.
Gene References into Functions
  1. DAZ-1 in C. elegans plays essential roles in female premeiotic and early meiotic germ cells, probably via regulating the translational activity of specific target genes required for the progression of oogenesis. PMID: 15572146
  2. daz-1 plays a role upstream of the pathway for germ cell sex determination. PMID: 16641369
  3. in a two hybrid assay,daz- as bait interacted with cpb-3 PMID: 16678151
  4. all germline samples studied were found to be free from AZFc microdeletions and CNP of the DAZ genes. PMID: 17308897
Protein Families
RRM DAZ family
Tissue Specificity
Germline specific. More strongly expressed during oogenesis than during spermatogenesis. During the larval stages, it is more abundant at the distal region than the proximal region of the gonad. In young adult hermaphrodites, it is expressed at a very low
Database Links

KEGG: cel:CELE_F56D1.7

STRING: 6239.F56D1.7

UniGene: Cel.6835

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