dcr-1 Antibody

1. Report of transcriptome-wide map of Dicer targets; identify thousands of Dicer-binding sites in human cells and C. elegans; find known and hundreds of additional miRNAs; also report structural RNAs, promoter RNAs, and mitochondrial transcripts as Dicer targets; most Dicer-binding sites reside on mRNAs/lncRNAs and are not significantly processed into small RNAs. PMID: 25416952
2. Cleavage of DCR-1 by caspase 3 may cause a conformational change that allows truncated DCR-1 to bind and process DNA, and may remove steric hindrance that blocks DNA access to truncated DCR-1. PMID: 24323044
3. [review] Dicer-1 lacks a functional helicase domain and is responsible for processing pre-microRNAs into mature miRNAs. PMID: 24556400
4. Taken together, these results uncover a previously unknown role for DCR-1/Dicer in C. elegans antibacterial immunity that is largely associated with miRNA processing. PMID: 23918784
5. Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode PMID: 21362554
6. the helicase domain of Dicer is not necessary for microRNA (miRNA) processing, or RNA interference following exposure to exogenous double-stranded RNA PMID: 20354150
7. findings show that DCR-1 functions in fragmenting chromosomal DNA during apoptosis, in addition to processing of small RNAs, and undergoes a protease-mediated conversion from a ribonuclease to a deoxyribonuclease PMID: 20223951
8. Our findings provide a first glimpse at the complex biochemical niche of Dicer and suggest that competition exists between DCR-1-mediated small-RNA pathways. PMID: 16439208
9. Knock-out animals Dcr-/- show increased expression of innate immunity genes. PMID: 17526642

Show More

Hide All

KEGG: cel:CELE_K12H4.8

STRING: 6239.K12H4.8

UniGene: Cel.38691