DHX58 Antibody

Datasheet
Code CSB-PA858739XA01MO
Product Type Polyclonal Antibody
Uniprot No. Q99J87
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Mus musculus (Mouse) DHX58 protein
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Probable ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor Lgp2) (RLR) Dhx58 D11lgp2e Lgp2
Immunogen Species Mus musculus (Mouse)
Gene Names Dhx58
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms
Subcellular Location Cytoplasm
Protein Families Helicase family, RLR subfamily
Tissue Specificity Highly expressed in mammary tissues. Expressed in liver and testis. Expressed at lower level in spleen, embryo, mammary gland and breast tumors.
Database Links

KEGG: mmu:80861

STRING: 10090.ENSMUSP00000017974

UniGene: Mm.271830

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