DHX58

DHX58 is the gene encoding the protein DExH-Box Helicase 58). Diseases associated with DHX58 include measles and rabies. Associated pathways include the innate immune system and NF-kappaB signaling. Gene Ontology (GO) annotations associated with this gene include nucleic acid binding and helicase activity. An important paralog of this gene is IFIH1. It acts as a regulator of DDX58/RIG-I and IFIH1/MDA5-mediated antiviral signaling. It cannot initiate antiviral signaling because it lacks the CARD domain required to activate MAVS/IPS1-dependent signaling events.