utp25 Antibody

Code CSB-PA764789XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) utp25 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
diexf antibody; defDigestive organ expansion factor antibody
Raised in
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) utp25 protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas. May not play a major role during the early stage of endodermal organogenesis. Also involved in the sympathetic neuronal development. Triggers the degradation of p53/TP53 and Delta113p53 isoform in a ubiquitination pathway independent way. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.
Gene References into Functions
  1. Fibrotic scar formation in def+/- is blocked by the over-expression of Def. PMID: 24801718
  2. Def can mediate the degradation of p53 protein and that this process is independent of the proteasome pathway, but dependent on the activity of Calpain3, a cysteine protease. PMID: 23357851
  3. Def functions in a cell autonomous manner during early liver development. PMID: 23593122
  4. def gene encodes a novel pan-endoderm-specific factor.p53 is tightly regulated by factor Def, especially during organogenesis PMID: 16322560
Subcellular Location
Nucleus, nucleolus.
Protein Families
Def family
Tissue Specificity
Mainly expressed in digestive organs at the later stage of organogenesis. Expressed in liver, gut and exocrine pancreas, but not in the islets.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
7505 Fannin St Ste 610-322 Houston, TX 77054, USA
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