dlg1 Antibody

1. The authors find that the tumor suppressor Discs large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindle orientation factor GukHolder (GukH). PMID: 29185419
2. The structure of dlg1 reveals that the core of the dimer is formed by a distinctive six-helix assembly, involving all three conserved helices from each subunit (monomer). The homodimer interface is extended by the C-terminal tail of the L27 domain of Dlg1, which forms a two-stranded antiparallel beta-sheet. The structure reconciles and provides a structural context for a large body of available mutational data. PMID: 29261291
3. Strikingly the absence of any of DLG proteins at the presynaptic terminal disrupts the clustering and localization of the calcium channel DmCa1A subunit (Cacophony), decreases the action potential-evoked release probability and alters short-term plasticity. PMID: 27573697
4. Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD). The data place Bnd at the top of the hierarchy of the factors involved in ACD, suggesting that its main function is mediating localization and function of Dlg tumor suppressor. PMID: 25088559
5. The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis. PMID: 25509107
6. Loss of scrib, dlg and lgl had no effect on gonad formation, but Dlg and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads. PMID: 23585349
7. Gliotactin and Discs large are co-regulated to maintain epithelial integrity. PMID: 23321643
8. Hts regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells. PMID: 21791202
9. Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg. PMID: 20810883
10. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization PMID: 20427642
11. Study provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. PMID: 19948068
12. integrins act through CaMKII activation to control the localization of dlg in the development of NMJ synaptic morphology PMID: 12091308
13. conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts PMID: 12545176
14. Isoforms of Dlg are fundamental for neuronal development in Drosophila PMID: 12657668
15. role in development of cell boundaries for cell nuclei in Drosophila embryos in conjunction with Strabismus protein PMID: 14562058
16. recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms; DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses PMID: 15039455
17. DLG controls glutamate receptor subunit (GluR) composition by selectively stabilizing GluRIIB subunit-containing receptors at the synapse. PMID: 15638945
18. Novel spatiotemporal patterns of epithelial tumor invasion in Drosophila disc large egg chambers were studied. PMID: 15712204
19. multiple interdomain interactions in the scaffold Discs Large (Dlg) regulate binding to the synaptic protein GukHolder (GukH) PMID: 16982606
20. DLG regulates the formation of sodium dodecyl sulfate-resistant target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes containing guanylate kinase-like-interacting syntaxin GTX. PMID: 17267557
21. Study identified a previously unrecognized evolutionarily conserved Pins domain (Pins(LINKER)) that requires Aurora-A phosphorylation to recruit Dlg and promote partial spindle orientation. PMID: 19766567

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KEGG: dme:Dmel_CG1725

STRING: 7227.FBpp0290503

UniGene: Dm.4352