dmbx1a Antibody

Code CSB-PA818294XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) dmbx1a Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
dmbx1a antibody; dmbx1 antibody; mbx antibody; mbx1 antibody; pox1Diencephalon/mesencephalon homeobox protein 1-A antibody; Paired homeobox protein 1 antibody
Raised in
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) dmbx1a protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Required for eye and tectum development. May act as a transcriptional repressor.
Gene References into Functions
  1. Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression. PMID: 25872183
  2. Data suggest that both zebrafish dmbx1a and dmbx1b genes are retained in the fish genome due to their requirement during midbrain and retinal neurogenesis, although their function is partially diverged. PMID: 20860823
  3. mbx homeobox gene is required for the development of the eyes and tectum. PMID: 12142024
  4. revealed a pattern of partial spatiotemporal expression divergence between the mbx paralogs that correlates with sequence divergence in noncoding regulatory domains PMID: 16733737
Subcellular Location
Protein Families
Paired homeobox family
Tissue Specificity
In embryos, expressed in mesencephalon with strongest expression dorsally, diencephalon, and rhombencephalon. During somitogenesis, anterior expression which partly overlaps the future eye field, gradually decreases while midbrain expression intensifies a
Database Links
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