DnaJ-1 Antibody

1. Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S PMID: 28158474
2. Through DnaJ-1, our data connect ataxin-3 and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species. PMID: 26007638
3. Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A PMID: 25954029
4. HSP40 and HSP110 function together in protein homeostasis control. PMID: 24091676
5. A high positive correlation was found between the levels of Hsp40 expression and scores of basal and induced thermotolerance, implying a significant contribution of Hsp40 gene in thermoadaptation. PMID: 21505045

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KEGG: dme:Dmel_CG10578

STRING: 7227.FBpp0076829

UniGene: Dm.2839