dnd Antibody

1. Homozygous dnd mutants became germ-cell-free males that are able to nurse donor-derived germ cells. PMID: 28731265
2. study showed that DND protein functions as a translation repressor of specific mRNAs to control PGC development in zebrafish PMID: 28115159
3. Balance between miRNA-430 function and the action of the RNA-binding protein Dead end, effectively transforms immotile primordial germ cells into polarized cells that actively migrate relative to cells in their environment. PMID: 22705393
4. Data show that hub RNA is a target of global miRNA-mediated repression, while the RNA-binding protein Dead end (Dnd) contributes to maintenance of the expression in the primordial germ cells (PGCs). PMID: 21337467
5. identification of target mRNA for ZDnd will be helpful to further explore the biological function of Dnd in zebrafish germ-line development as well as in cancer cells PMID: 20587335
6. Dnd ATPase is involved in protecting primordial germ cell nanos1 and TDRD7 transcripts. PMID: 20371629
7. Knockdown of dead end blocks confinement of primordial germ cells (PGCs) to the deep blastoderm shortly after their specification and results in failure of PGCs to exhibit motile behavior and to actively migrate thereafter. PMID: 12932328
8. Unravel a novel role of dead end 1 (Dnd1) in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
9. Cis-acting elements within dnd mRNA and the RNA recognition motive (RRM) of the protein are essential for targeting protein expression to the germ cells and to the perinuclear granules, respectively. PMID: 19013519

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KEGG: dre:373074

STRING: 7955.ENSDARP00000035017

UniGene: Dr.26907