dnk Antibody

1. We showed that sensitivity of the osteosarcoma cell line to the nucleoside analogs and the efficiency of bystander cell killing were independent of the subcellular localization of Dm-dNK. PMID: 26134602
2. Report synergistic antitumor effect of adenovirus armed with Drosophila melanogaster deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma. PMID: 26203222
3. Data indicate that long term Dm-dNK ( nucleoside kinase from Drosophila melanogaster) expression rescued thymidine kinase 2 (Tk2)-deficient mice without lethal side effects. PMID: 25296759
4. Multisubstrate deoxyribonucleoside kinase could be used in a novel therapeutic strategy for treating breast cancer and improving anti-tumor efficacy, as well as for optimizing approaches for suicide gene therapy. PMID: 21674733
5. mechanism of feedback inhibition is presented based on the crystal structure of a complex between deoxyribonucleoside kinase and its feedback inhibitor deoxythymidine triphosphate PMID: 12741827
6. Results describe active-site mutants of Drosophila deoxyribonucleoside kinase (Dm-DNK) with reduced phosphorylation efficiency, supporting their importance for substrate binding and/or catalysis as proposed by the recently solved structure of Dm-dNK. PMID: 12823558
7. mutation N64D is responsible for decreasing activity towards the natural substrates PMID: 16008571
8. This strongly suggests that dNK plays a role in cell proliferation in physiological conditions. PMID: 16582629
9. observations give insight into the mechanisms of substrate binding and catalysis, which is important for developing novel suicide genes and drugs for use in gene therapy PMID: 17302737
10. Structural studies of nucleoside analog and feedback inhibition binding to Drosophila melanogaster multisubstrate dnk are reported. PMID: 18384378

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KEGG: dme:Dmel_CG5452

STRING: 7227.FBpp0302815

UniGene: Dm.1248