DOP1B Antibody

Code CSB-PA897108XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOP1B Polyclonal antibody
Uniprot No.
Target Names
DOP1B
Alternative Names
DOP1B antibody; C21orf5 antibody; DOPEY2 antibody; KIAA0933Protein dopey-2 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) DOP1B protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation.
Gene References into Functions
  1. The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in Down syndrome. PMID: 12767918
  2. C21orf5 selective expression in the key brain structures for learning and memory suggests that C21orf5 overexpression could participate in mental retardation pathogenesis in Down syndrome patients. PMID: 16276086
  3. C21orf5, could play a role in brain morphogenesis and, when overexpressed, it could participate in neurological features and mental retardation observed in DS patients. PMID: 16303751
  4. Results quantify and statistically analyze, for the first time, DOPEY2 expression variations in different regions of the Down syndrome human fetal brains and to compare them to corresponding normal brains. PMID: 19460634
Subcellular Location
Early endosome membrane. Golgi apparatus membrane; Peripheral membrane protein.
Protein Families
Dopey family
Tissue Specificity
Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.
Database Links

HGNC: 1291

OMIM: 604803

KEGG: hsa:9980

STRING: 9606.ENSP00000382104

UniGene: Hs.204575

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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