dnaX Antibody

1. study characterized the dnaXE145A clamp loader mutant; found that the naturally occurring obstacles encountered by a replication fork are not tackled in a proper way by the mutant clamp loader and suggest a role for the clamp loader in the restart of stalled replication forks PMID: 28947673
2. Ribosome frameshifting during translation of bacterial dnaX can proceed via different routes, generating a variety of distinct polypeptides. PMID: 28525745
3. Data show that expression from DNA polymerase III dnaX to produce gamma subunit is essential for normal cellular function. PMID: 26786318
4. Destabilization of the single-stranded DNA-chi subunit of DNA polymerase III complex in vivo produces cells with temperature- dependent cell cycle defects that appear to arise from replisome instability. PMID: 21857649
5. Analyzing DnaX complexes containing one or more K51E variant DnaX subunits demonstrated that only one active ATP binding site is required to form initiation complexes, but the two additional sites increase the rate by ca 1000-fold. PMID: 21820444
6. Only one ATP-binding DnaX subunit is required for initiation complex formation by the Escherichia coli DNA polymerase III holoenzyme. PMID: 20675375
7. tau subunit plays an important role in determining the fidelity of the chromosomal replication, specifically in the avoidance of transversions and frameshift mutations. PMID: 16430690
8. data suggest that the unstructured C-terminus of tau subunit of Escherichia coli DNA polymerase III holoenzyme becomes folded into a helix-loop-helix in its complex with alpha subunit. PMID: 17355988
9. The interaction site of protein domains of of the tau subunit of Escherichia coli DNA polymerase III on the alpha subunit was mapped by NMR experiments. PMID: 17452361
10. Data support the assumption that dnaX36-mediated mutations originate as errors of replication rather than DNA damage-related events. PMID: 18156258
11. The DNA polymerase III clamp loading reaction can be divided into two stages: formation of a ternary clamp loader.clamp.DNA complex, and decay of the ternary complex to produce a clamp.DNA complex. Clamp release is likely to be the rate-limiting step. PMID: 19663416

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KEGG: ecj:JW0459

STRING: 316385.ECDH10B_0426