shi Antibody

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Code	CSB-PA326735XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) shi Polyclonal antibody

Uniprot No.

P27619

Target Names

shi

Alternative Names

shi antibody; CG18102Dynamin antibody; EC 3.6.5.5 antibody; Protein shibire antibody; dDyn antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) shi protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.

Gene References into Functions

results implicate mutant dynamin as an effective seizure suppressor, suggesting that targeting or limiting the availability of synaptic vesicles could be an effective and general method of controlling epilepsy disorders PMID: 26341658
These studies identify novel morphogenetic roles (i.e., tube closure and biased apical expansion), and expand upon established roles (i.e., cell intercalation and adhesion remodeling), for Dynamin in tubulogenesis. PMID: 26542010
Dynamin is critically involved in the stabilization of Clathrin- and AP2-dependent endocytic pits. PMID: 24662566
The shibire gene product, Dynamin, appears to be required for an immediate early response to ethanol that triggers a cellular response leading to rapid functional tolerance. PMID: 21797886
A temperature sensitive shibire mutant was used to trap synaptic vesicles at the plasma membrane and extracted sterols from synaptic vesicles. PMID: 21106824
Mutation in shibire causes male-male courtship behavior due to disruption of synaptic transmission PMID: 12239352
The shi(ts1) mutation induces a conformational change, involving the GTP binding site, that affects dynamin aggregation. PMID: 12382260
Expression of a temperature-sensitive shibire (shi) transgene in a subset of alpha/beta neurons resulted in odor-pair-specific disruption of learning. PMID: 16980542
DRP mutants affect synaptic transmission in a manner similar to the Drosophila sesBorg mutants. Mitochondria with abnormal morphology in DRP mutants might lead to a deficit in ATP levels or lowered rates of ATP repletion at the synapse. PMID: 17233640

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Database Links

KEGG: dme:Dmel_CG18102

STRING: 7227.FBpp0305866

UniGene: Dm.3444

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shi Antibody

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