Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EIF3B Polyclonal antibody

Uniprot No.

P55884

Target Names

EIF3B

Alternative Names

eIF-3-eta antibody; eIF3 eta antibody; eIF3 p110 antibody; eIF3 p116 antibody; EIF3-ETA antibody; EIF3-P110 antibody; EIF3-P116 antibody; eIF3b antibody; EIF3B_HUMAN antibody; EIF3S9 antibody; EIF3S9; formerly antibody; Eukaryotic translation initiation factor 3; subunit B antibody; Eukaryotic translation initiation factor 3 subunit 9 antibody; eukaryotic translation initiation factor 3 subunit 9 eta antibody; Eukaryotic translation initiation factor 3 subunit B antibody; eukaryotic translation initiation factor 3; subunit 9 (eta; 116kD) antibody; eukaryotic translation initiation factor 3; subunit 9 eta; 116kDa antibody; eukaryotic translation initiation factor 3; subunit 9; formerly antibody; hPrt1 antibody; Protein synthesis defective at 36 degrees celsius 1; S. cerevisiae; homolog of antibody; PRT1 antibody; Prt1 homolog antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) EIF3B protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.

Gene References into Functions

Study demonstrated that EIF3B expression was up-regulated in esophageal squamous cell carcinoma cells and negatively correlated with the prognosis of patients. PMID: 27270324
Novel RNA-binding protein P311 binds eIF3b to promote translation of TGF-beta1, TGF-beta2, TGF-beta3. PMID: 25336651
Report EIF3B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
eIF3b expression relates to human bladder and prostate cancer prognosis, is required for tumor growth, and thus a candidate therapeutic target. PMID: 23575475
EIF3B promotes the proliferation of U87 human glioblastoma cells and may play an important role in human glioblastoma development. PMID: 22234522
Yeast eIF3b exhibits RNA binding activity but huamn eIF3b doesn't. PMID: 20862284
a conserved tryptophan residue in the human eIF3j N-terminal acidic motif (NTA) is held in the helix alpha1 and loop 5 hydrophobic pocket of the human eIF3b RNA recognition motif (RRM) PMID: 20060839
structural analysis of the eIF3b RNA recognition motif and its interaction with eIF3j PMID: 17190833

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Subcellular Location

Cytoplasm.

Protein Families

EIF-3 subunit B family

Database Links

HGNC: 3280

OMIM: 603917

KEGG: hsa:8662

STRING: 9606.ENSP00000354125

UniGene: Hs.371001

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