EIF4G1 Antibody

Code CSB-PA007568ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) EIF4G1 Polyclonal antibody
Uniprot No. Q04637
Target Names EIF4G1
Alternative Names DKFZp686A1451 antibody; eIF 4 gamma 1 antibody; eIF 4G 1 antibody; eIF 4G1 antibody; eIF-4-gamma 1 antibody; eIF-4G 1 antibody; eIF-4G1 antibody; EIF4 gamma antibody; EIF4F antibody; EIF4G antibody; EIF4G1 antibody; EIF4GI antibody; Eukaryotic translation initiation factor 4 gamma 1 antibody; IF4G1_HUMAN antibody; p220 antibody
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Human Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), partial (1250-1599AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

Target Data

Function Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Gene References into Functions
  1. The polymorphism of the rs200221361 may have no association with the occurrence of Parkinson disease in Uygur and Han people of Xinjiang. PMID: 29718834
  2. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation. PMID: 29142127
  3. EIF4G1 overexpression is associated with non-small cell lung cancers. PMID: 27003362
  4. High EIF4G expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas. PMID: 26951381
  5. The study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in Parkinson's disease. PMID: 26490695
  6. the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G). PMID: 27525590
  7. EIF4G1 mutations are not related to Parkinson's disease PMID: 26022768
  8. VPS35 D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population. PMID: 26300542
  9. EIF4GI shares this activity and also interacts with eIF1. PMID: 25738462
  10. EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts. PMID: 25368108
  11. This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes PMID: 25593313
  12. Knockdown of eIF4GI was deleterious to myeloma cells phenotype and expression of specific molecular targets (SMAD5/ERalpha/HIF1alpha/c-Myc). PMID: 24815186
  13. Its mutation is not a common cause of familial Parkinson's disease. PMID: 24854799
  14. in a generic cell model, new insights into the mechanisms whereby the FSH receptor controls translation have been gained. Rapamycin-sensitive eIF4G phosphorylation at the 5' cap may be a surrogate for the classical exchange between eIF4G and 4E-BP1. PMID: 24711644
  15. The results of this study did not identify novel or previously reported pathogenic mutations (including the p.A502V and p.R1205H mutants) within EIF4G1 in the Japanese population. PMID: 24704100
  16. Data suggest that, in eIF4G/eif4A complex, eIF4G1 exhibits low-affinity ATP binding site in proximity of ATP-binding cleft of eif4A enhancing ATP binding; additional enhancement of eIF4G/eif4A binding is observed in crowded/intracellular environment. PMID: 25255371
  17. study revealed that the EIF4G1 R1205H and VPS35 D620N mutations were absent in 418 Parkinsoin Disease patients of various South African ethnic groups PMID: 24080171
  18. Report EIF4G binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
  19. Its mutation causes Parkinson's disease in Indian population. PMID: 23726718
  20. eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
  21. EIF4G1 mutations do not appear to play a role in patients with Parkinson disease from southwest China. PMID: 23261770
  22. The eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimulate eIF4A helicase activity. PMID: 23901100
  23. The data of this study indicated that in an ethnic Chinese population, the pathogenic mutation p.R1205H in EIF4G1 is not common and that EIF4G1 exonic variants rs2178403 and rs13319149 are not associated with parkinson disease. PMID: 23617574
  24. The results suggest that in some patients variants in EIF4G1 can be associated with pathology that has a high likelihood of association with clinical features of dementia with Lewy bodies. PMID: 23124435
  25. the EIF4G1 p.Ala502Val and p.Arg1205His variants are a rare cause of PD, at least in Chinese population. PMID: 23562511
  26. In agreement with recent reports we conclude that convincing evidence establishes EIF4G1 mutations as a rare cause of Parkinson's disease PMID: 23490116
  27. eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex. PMID: 23409027
  28. EIF4G1 is an uncommon cause of PD in our Asian cohort. PMID: 23092605
  29. There is no evidence for an overall contribution of genetic variability in EIF4G1 (or VPS35) to Parkinson disease development in this large family. PMID: 23408866
  30. Results provide a mechanistic link between intracellular signal transduction and dynamic initiation complex formation coordinated by flexible eIF4G structure. PMID: 23263986
  31. Data show that eIF4G interacts with the RRM2 domain of polyadenylate-binding protein-1 (PABP). PMID: 23041282
  32. Increased expression of eIF4G1 therefore promotes specialized translation of survival, growth arrest, and DDR mRNAs that are important in cell survival and DNA repair following genotoxic DNA damage. PMID: 23112151
  33. EIF4G1 cDNAs, encoding different isoforms which arise through selection of alternative initiation codons, rescued translation from siRNA interference to different extents PMID: 22909319
  34. analysis of variants of eukaryotic translation initiation factor 4G1 in sporadic Parkinson\'s disease PMID: 22707335
  35. These data do not support the pathogenicity of several EIF4G1 variants in PD, at least in the French population. PMID: 22658323
  36. linkage analysis, mutations in EIF4G1 were implicated as a cause of Parkinson disease and mutations in SLC20A2 as a cause of familial idiopathic basal ganglia calcification. PMID: 22772876
  37. Found that either EIF4G1 variants are an extremely rare cause of familial Parkinson's Disease in Caucasian cohorts, or that A502V is in fact a rare benign variant not involved in Parkinson's Disease aetiology PMID: 22561553
  38. This finding demonstrates that viruses can increase host translation initiation factor concentration to foster their replication and defines a unique mechanism whereby control of PABP abundance regulates eIF4F assembly. PMID: 22431630
  39. The ssDNA-binding protein of Vaccinia virus, I3 interacts and co-localizes with the eIF4F scaffold protein, eIF4G inInfected cells. PMID: 22280895
  40. EIF4G1 mutations implicate mRNA translation initiation in familial parkinsonism. PMID: 21907011
  41. Data show that PKCalpha activation elicits a cascade of orchestrated phosphorylation events that may modulate eIF4G1 structure and control interaction with the eIF4E kinase, Mnk1. PMID: 21576361
  42. EIF4G1 can serve as a biomarker for the prognosis of nasopharyngeal carcinoma patients. PMID: 20398343
  43. HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage PMID: 19956697
  44. findings assign NAD(P)H quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome. PMID: 20028737
  45. mass spectrometric analysis of N terminus reveals novel isoforms PMID: 11821405
  46. demonstrate that the expression of the amino-terminal one-third of eIF4G, which interacts with eIF4E and PABP, in Xenopus oocyte inhibits translation and progesterone-induced maturation PMID: 11866104
  47. data suggest that expression of the eIF4GI isoforms is partly controlled by a complex translation strategy involving both cap-dependent and cap-independent mechanisms PMID: 12052860
  48. X-ray structure of rotavirus NSP3-C bound to the 30 residue fragment of eIF4G that is also recognized by poly(A) binding protein (PABP) PMID: 12086624
  49. proteolytic activity of HIV-1 protease on eIF4GI and eIF4GII and its implications for the translation of mRNAs PMID: 12505164
  50. Overexpression of EIF4G1 causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules. PMID: 12581158
  51. cleavage of EIF4G by Coxsackievirus 2A protease enhances the translation efficiency of EV71 IRES activity PMID: 14592777
  52. RoXaN is capable of interacting with NSP3 and eIF4G I in vivo and during rotavirus infection. Domains of interaction were mapped. PMID: 15047801
  53. Expression of fragments of eIF4GI reveals a nuclear localization sequence within the N-terminal apoptotic cleavage fragment N-FAG. PMID: 15128869
  54. eIF4F activation is an essential component of the malignant phenotype in breast carcinoma PMID: 15193258
  55. eIF4G binding to Mnk is inhibted by Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK PMID: 15234964
  56. role of binding to adenoviral mRNA in ribosome shunting PMID: 15314025
  57. phoshorylation induced by human Cytomegalovirus infections is both mTOR and phosphatidylinositol kinase independent. PMID: 15452223
  58. intact eIF4GI protein is not required for the de novo synthesis of eIF4GI, suggesting its expression can continue under stress or infection conditions where eIF4GI is cleaved PMID: 15755734
  59. Results identify two conserved basic residues (K646 and R650) in human eukaryotic initiation factor 4GI (eIF4GI) that are important for foot-and-mouth disease virus leader proteinase binding. PMID: 15885108
  60. The organization of the CBP80-CBP20 complex suggests how the activity of eIF4G in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions. PMID: 16156639
  61. Citrullinated eIF4G1 was identified as a candidate citrullinated autoantigen in RA patients. PMID: 16412378
  62. The X-ray structure of the C-terminal region of human eukaryotic translation initiation factor 4G (eIF4G) has been determined at 2.2 A resolution, revealing two atypical HEAT-repeat domains. PMID: 16698552
  63. eIF3e binds to eIF4G during the process of cap-dependent translation initiation PMID: 16766523
  64. We quantify the efficiency of eIF4GI promoter usage in mammalian cells and demonstrate that even though the longest isoform eIF4GIf was relatively poorly expressed when reintroduced, it was more efficient at promoting the translation of cellular mRNAs. PMID: 16982693
  65. Data show that coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5. PMID: 17195095
  66. Results show that three genes, namely FXR1, CLAPM1 and EIF4G, are most frequently overexpressed in the center of the amplified domain in squamous cell carcinomas. PMID: 17290396
  67. High levels of eIF4GI observed in many cancers might act to specifically increase proliferation, prevent autophagy, and release tumor cells from control by nutrient sensing. PMID: 18426977
  68. nuclear localization of PABP-C1 not only is dependent on the capacity of rotavirus NSP3 to interact with eIF4G but also requires the interaction of NSP3 with a specific region in RoXaN PMID: 18799579
  69. eIF4GI serves to anchor eIF4E to the mRNA and enhance its interaction with the cap structure. PMID: 19114555
  70. Data show that the unique pathogenic properties of IBC result in part from overexpression of the translation initiation factor eIF4GI in most inflammatory breast cancer. PMID: 19525934
  71. eIF4GI does not colocalize with ribosomes in VSV-infected cells, while eIF2alpha locates at perinuclear sites coincident with ribosomes. PMID: 19769989

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Involvement in disease Parkinson disease 18 (PARK18)
Protein Families Eukaryotic initiation factor 4G family
Database Links

HGNC: 3296

OMIM: 600495

KEGG: hsa:1981

STRING: 9606.ENSP00000338020

UniGene: Hs.433750

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