emr-1 Antibody

Code CSB-PA519041XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans emr-1 Polyclonal antibody
Uniprot No.
Target Names
emr-1
Alternative Names
emr-1; M01D7.6; Emerin homolog 1; Ce-emerin
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans emr-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation-induced DNA damage repair response.
Gene References into Functions
  1. We demonstrate a specific role of EMR-1 in neuromuscular junction activity that may contribute to Emery-Dreifuss muscular dystrophy in humans PMID: 24490688
  2. these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle. PMID: 22171324
  3. LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy PMID: 12684533
Subcellular Location
Nucleus envelope. Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side.
Tissue Specificity
Ubiquitous. Expressed in all cells, except in cells undergoing spermatogenesis.
Database Links

KEGG: cel:CELE_M01D7.6

STRING: 6239.M01D7.6.1

UniGene: Cel.18441

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