env Antibody

1. BST2B acts differently from BST2A by leading to a reduction in Jaagsiekte sheep retrovirus Env incorporation into viral particles, which ultimately results in the release of virions that are less infectious. PMID: 25339764
2. study reveals critical determinants in SU subunits of JSRV and ENTV Env proteins that likely regulate their local structure and thereby differential receptor-mediated fusion activation at low pH; findings explain, in part, their distinct viral infectivity PMID: 22018783
3. The authors observed that Env of Jaagsiekte sheep retrovirus induced the expression of a tumor suppressor, Sprouty2, suggesting a correlation between Env-effect and Sprouty2 expression. PMID: 20678191
4. These data strongly suggest that the JSRV Env functions as a dominant oncoprotein in the natural immunocompetent host and that JSRV can induce ovine pulmonary adenocarcinoma in the absence of viral spread. PMID: 16873259
5. The role of the env transmembrane cytoplasmic tail in JSRV transformation was studied. PMID: 16873263
6. JSRV Env protein is capable of inducing tumors in transgenic mice, and in other cell types besides lung epithelial cells. PMID: 17043760
7. signal peptide of the JSRV Env (JSE-SP) is 80 amino acid residues in length and contains putative nuclear localization and export signals, in addition to an arginine-rich RNA binding motif PMID: 19244321
8. In this study, the authors found that the betaretrovirus Jaagsiekte sheep retrovirus (JSRV) encodes within the env gene a trans-acting factor (Rej) necessary for the synthesis of Gag protein from unspliced viral RNA. PMID: 19776124
9. Rej response element-containing RNA relocalized Rej protein from the nucleus to the cytoplasm in 293 and rat 208F cells, suggesting binding of Rej to the Rej response element. PMID: 19776134

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KEGG: vg:1490021