esg Antibody

1. Esg controls specification of cell types in trachea and suppresses ERK signaling in fusion cells to control cells' differential migratory behavior. PMID: 27742749
2. Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs PMID: 27471258
3. CySCs mutant for esg are not maintained as stem cells, but remain capable of differentiating normally along the cyst cell lineage. In contrast, esg mutant CySCs that give rise to a closely related lineage, the apical hub cells, cannot maintain hub cell identity. this dual regulatory role is due to simultaneous control by Esg of overlapping genetic programs. Similar results were obtained with intestinal stem cells. PMID: 27077690
4. Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch. PMID: 26077448
5. Cell type-specific transcriptome analysis combined with Dam-ID binding studies identified Esg as a major repressor of differentiation genes in stem and progenitor cells. PMID: 25298397
6. Authors demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through modulation of Notch activity. PMID: 25433031
7. Escargot protein as an essential factor is required in hub cells for maintaining niche integrity by blocking conversion of hub cells to the cyst cell lineage. PMID: 24794442
8. Escargot directly interact with Daughtherless and its mammalian homologue HEB and eliminate them through siah-1 mediated protein degradation. PMID: 20647756
9. role as an enhancer trap that monitors male-specific gene expression in germ cells PMID: 11902678
10. snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu. PMID: 15110709
11. esg must be ectopically expressed during nervous system development to reduce seizure susceptibility in adult drosophila. PMID: 15654097

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KEGG: dme:Dmel_CG3758

STRING: 7227.FBpp0080293

UniGene: Dm.4764