EST1 Antibody

1. Recruitment of Est1 to telomeres via a Cdc13-Est1 fusion is sufficient to bypass the role of Ku in promoting telomere elongation. PMID: 24879463
2. Autonomous localization of Est1p to the nucleus via the classical nuclear import pathway contributes to normal telomere length maintenance. PMID: 24906415
3. Esl1 has no telomere-related functions, but contributes to the regulation of adaptive gene expression responses. PMID: 23893744
4. It is possible that the intramolecular G-quadruplex promoting activity of Est1 is biologically relevant in telomere replication in vivo. PMID: 23376615
5. There is a biochemical interaction between Est1 and the telomere binding protein Cdc13. Association of the Est1 protein with the telomerase catalytic core is not a regulatory event that contributes to telomere homeostasis. PMID: 23390975
6. the telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro PMID: 21969561
7. The tricotetrapeptide repeat of Est1 is required for Est2-mediated telomere length maintenance. PMID: 22011238
8. These results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres. PMID: 21220516
9. The authors show that the yeast telomerase subunit Est1p, known to be involved in telomerase recruitment to telomeres, can convert single-stranded telomeric G-rich DNA into a G-quadruplex structure in vitro in a Mg(2+)-dependent manner. PMID: 20098422
10. telomerase assembly during G1 phase is regulated by Est1p stability, but assembly is insufficient to activate telomerase at telomeres PMID: 16862158
11. dimerization of TLC1 is a functionally conserved feature of the RNA templates utilized by reverse transcriptases of both viral and cellular origins PMID: 17491007
12. Maintenance of functional levels of Est2p late in the cell cycle requires that Est1p. PMID: 18949040

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KEGG: sce:YLR233C

STRING: 4932.YLR233C