exd Antibody

1. Hth functions together with its co-factor Extradenticle to repress the R8-specific factor Senseless in dorsal rim area R8 cells, allowing expression of an ultraviolet-sensitive R7 Rhodopsin. PMID: 24496628
2. cooperative binding sites for En, with the homeodomain-containing Hox cofactors Extradenticle (Exd) and Homothorax (Hth) was localized, within two CRMs that drive similar expression patterns PMID: 22537495
3. In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F. PMID: 22975331
4. Using computational platform, SELEX-seq, study shows that all eight Drosophila Hox proteins obtain novel recognition properties when they bind DNA with the dimeric cofactor Extradenticle-Homothorax. PMID: 22153072
5. Homothorax and extradenticle control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain. PMID: 21801717
6. Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity. PMID: 21262810
7. Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. PMID: 12070087
8. in thoracic segments, Exd is required for repression (as well as activation) by En. This is consistent with in vitro results showing that Exd is involved in recognition of positive and negative targets. PMID: 12506003
9. we show that the functions of both of the Hox cofactors Extradenticle and Homothorax play essential roles in repression by Engrailed. PMID: 12506004
10. Labial, Ultrabithorax, Antennapedia, Extradenticle and Homothorax are regulated in a signal transduction pathway in developing Drosophila brain PMID: 15172684
11. homothorax/extradenticle is repressed in the body regions where eyg is active PMID: 15634705
12. distinct Hox/Exd/Hth complexes select different binding sites, and a given complex recognizes a consensus DNA sequence PMID: 15753213
13. Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells PMID: 16007069
14. nuclear EXD is more extensively phosphorylated than the cytoplasmic form, suggesting that EXD is a target of signal transduction by protein kinases PMID: 16403493
15. Exd contains an NLS mask that contributes to its cytoplasmic localization. PMID: 17277370
16. This finding highlights that the Hox protein Ubx has multiple ways to interact with the Exd cofactor and suggests that flexibility in Hox-PBC contacts contributes to specify and diversify Hox protein function. PMID: 17942685

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KEGG: dme:Dmel_CG8933

STRING: 7227.FBpp0073940

UniGene: Dm.174