Fabp1 Antibody

1. Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced. PMID: 27117865
2. L-FABP structurally and functionally interacts with HNF4alpha. PMID: 24140341
3. These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG PMID: 23658011
4. Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle. PMID: 22303004
5. NMR study of liver fatty acid-binding protein PMID: 21226535
6. Clofibrate enhanced L-FABP gene transcription and mRNA stability, thus affecting L-FABP expression and ultimately cellular antioxidant activity. PMID: 21102658
7. a direct role of glucose in facilitating L-FABP-mediated uptake and distribution of lipidic ligands to the nucleus for regulation of PPARalpha transcriptional activity PMID: 20628144
8. Data show that niacin therapyreduced renal tissue lipids, CD36, ChREBP, LXR, ABCA-1, ABCG-1, and SR-B1 abundance and raised PPAR-alpha and L-FABP. PMID: 19878707
9. The results support the concept that ligands with a bulky anionic head group bind at site 2 of liver fatty acid binding protein where solvent exposure allows the accommodation of their bulky anionic group. PMID: 12479568
10. The helical domain of liver FABP is able to convert the fatty acid transfer properties of intestinal FABP to those of liver FABP. These short (six to eight residues) helical segments can now be appreciated as novel motifs. PMID: 15035630
11. time course of changes in L-FABP mRNA and protein levels during liver regeneration following partial hepatectomy PMID: 15532708
12. The localization and possible function of Fabp1 in liver peroxisomes is described and discussed. PMID: 16262600
13. These results are consistent with tethering of one GATA factor to the Fabp1 promoter through interaction with a second GATA factor to produce increased target gene activation. PMID: 16603485
14. reducing both L-FABP and microsomal triglyceride transfer protein is an effective means to reduce very low density lipoprotein secretion without causing hepatic steatosis PMID: 16950764
15. L-FABP can select cargo for and bud PCTV from intestinal ER membranes PMID: 17449472
16. Esterification patterns of fatty acids L-FABP-bound or free into nuclear lipids were the same whereas in the nuclear matrix, L-FABP could play an important role in the mobilization of 20:4n-6 into specific sites of utilization such as the PtdIns pools. PMID: 17551764
17. Solution-state molecular structure of apo and oleate-liganded liver fatty acid-binding protein. PMID: 17927211

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KEGG: rno:24360

STRING: 10116.ENSRNOP00000008841

UniGene: Rn.36412