kug Antibody

Code CSB-PA896159XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) kug Polyclonal antibody
Uniprot No.
Target Names
kug
Alternative Names
kug antibody; fat2 antibody; CG7749 antibody; Fat-like cadherin-related tumor suppressor homolog antibody; Protein kugelei antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) kug protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells. Required for proper egg chamber shape and elongation of the egg chamber during oogenesis. Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation.
Gene References into Functions
  1. Data show that the atypical cadherin Fat2 directs and orchestrates transmission of the intracellular actomyosin asymmetry cue onto a tissue plane and facilitate epithelial rotation in the opposite direction. PMID: 29176774
  2. Concordant microtubule polarity, but not microtubule alignment, requires the atypical cadherin Fat2, which acts at an early stage to translate plus-end bias into coordinated actin-mediated collective cell migration. PMID: 27134170
  3. Planar polarized localization of Fat2 depends on intact microtubules.Microtubule polarity depends on the atypical cadherin Fat2. PMID: 23831293
  4. Fat2 is required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells PMID: 19906848
  5. fat-like gene of Drosophila is involved in the formation of tubular organs PMID: 15047711

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Note=Accumulates on cell membranes where the planar oriented actin filaments terminate.
Tissue Specificity
Localizes where basal actin filaments terminate.
Database Links

KEGG: dme:Dmel_CG7749

STRING: 7227.FBpp0304968

UniGene: Dm.3778

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