FERM2 Antibody

Datasheet
Code CSB-PA291570XA01DIL
Product Type Polyclonal Antibody
Uniprot No. F1Q8X5
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) FERM2 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Fermitin family homolog 2 (Kindlin-2) fermt2
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names fermt2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling (By similarity). Required for normal embryonic development, including normal heart morphogenesis and normal angiogenesis.
Subcellular Location Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, Cell junction, focal adhesion, Membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, lamellipodium membrane, Peripheral membrane protein, Cytoplasmic side, Nucleus, Cytoplasm, myofibril, sarcomere, I band, Cell surface
Protein Families Kindlin family
Database Links

KEGG: dre:553051

STRING: 7955.ENSDARP00000049463

UniGene: Dr.83795

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