Fez1 Antibody

Code CSB-PA008600XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Fez1 Polyclonal antibody
Uniprot No.
Target Names
Fez1
Alternative Names
Fez1Fasciculation and elongation protein zeta-1 antibody; Zygin I antibody; Zygin-1 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Fez1 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.
Gene References into Functions
  1. Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. PMID: 27247180
  2. DISC1 participates in neurite outgrowth through its interaction with FEZ1. PMID: 12874605
  3. FEZ1 showed high levels of expression, especially in developing hippocampal neurons. PMID: 14992819
  4. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation PMID: 15466860
  5. FEZ1 promotes neurite extension through its interaction with microtubules, and agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules PMID: 15843383
  6. Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. PMID: 15879557
  7. Therefore, our results strongly suggest that FEZ1 participates in the establishment of neuronal polarity by controlling the mitochondrial motility along axon. PMID: 17173861
  8. the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells. PMID: 17669366
  9. Immunocytochemistry revealed that FEZ1 was located in the astrocytic cytoplasm and cell processes but not the nucleus PMID: 19199094
  10. FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1 PMID: 19667186

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
Protein Families
Zygin family
Tissue Specificity
Brain.
Database Links
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