flhD Antibody

1. three IS elements, IS1, IS3 and IS5, transpose to multiple upstream sites within a 370 bp region of the flhDC operon control region. The data are consistent with the possibility that appropriate environmental conditions, namely those that permit but hinder flagellar rotation, result in the activation of a mutational pathway that involves IS element insertion upstream of the flhDC operon. PMID: 28100305
2. Mutations in the flhD can exert positive or negative effects on motility. PMID: 27821046
3. FlhD is part of flagellar regulatory network. PMID: 25275371
4. Upregulation of fliZ by NtrC-sigma(N) was shown to be indirect and required an intact flagellar regulator flhDC. PMID: 24931910
5. Authors report that not only integrations of IS insertion sequences into the regulatory region of the flhDC operon, but also a missense mutation in the lrhA gene enhances motility by relieving transcriptional repression of the flhDC operon. PMID: 23456724
6. CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage. PMID: 23305111
7. Study demonstrates that insertion sequence IS5 in Escherichia coli inserts into the upstream region of the flhDC operon in a manner that depends on whether the environment permits motility. PMID: 21390082
8. Mutations in the flhD do not affect cell division. PMID: 20546312
9. These results indicate that the accumulation of sigmaS is one of the causes of the repression of transcription of flhD. PMID: 20185506
10. IS element insertion may activate transcription of the flhD operon by reducing transcriptional repression. PMID: 15516564
11. The data indicate a wider FlhD(2)C(2) regulon, in which non-flagellar genes are bound and activated directly PMID: 15941987
12. flhDC mutants of Escherichia coli are nonmotile, better colonize in the intestine, and better utilize sugars than wild type bacteria and Entner-Doudoroff pathway mutants. PMID: 16299298
13. crystallographic structure of the Escherichia coli FlhDC complex has been solved to 3.0 A resolution PMID: 16337229

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KEGG: ecj:JW1881

STRING: 316385.ECDH10B_2033