Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Fmo3 Polyclonal antibody

Uniprot No.

P97501

Target Names

Fmo3

Alternative Names

Fmo3Dimethylaniline monooxygenase [N-oxide-forming] 3 antibody; EC 1.14.13.8 antibody; EC 1.14.14.73 antibody; Dimethylaniline oxidase 3 antibody; Hepatic flavin-containing monooxygenase 3 antibody; FMO 3 antibody; Trimethylamine monooxygenase antibody; EC 1.14.13.148 antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Fmo3 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.

Gene References into Functions

Diabetes induced the expression of both Fmo3 and ICAM expression and possible vascular impairment through enteric dysbiosis. Diabetes-induced Fmo3 and ICAM expression could be reversed by pJNK inhibition or by correcting enteric dysbiosis. PMID: 29851956
The suppression of FMO3 metabolism related to reversible S-nitrosyl modifications of iNOS-derived NO in type 1 allergic mice. PMID: 28760731
knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) confers protection against obesity in mice. PMID: 28636934
FMO3 can contribute to the regulation of glucose metabolism in the liver by reducing lipid-induced endoplasmic reticulum stress and the expression of PEPCK, independently of insulin signal transduction. PMID: 26886171
FMO3 is increased in obese/insulin resistant male mice and necessary for expression of FoxO1. PMID: 25849138
Fmo3 expression and function plays a role in protecting the liver from acetaminophen-induced toxicity. PMID: 24973094
a major role for FMO3 in modulating glucose and lipid homeostasis PMID: 25378658
Report temporal changes in hepatic Fmo3 gene expression under different conditions all known to cause hepatic oxidative stress. PMID: 25193093
Report selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in SCID mice. PMID: 22745333
The functional activity of Fmo3 was determined. PMID: 17721934

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Subcellular Location

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Protein Families

FMO family

Tissue Specificity

Liver.

Database Links

KEGG: mmu:14262

STRING: 10090.ENSMUSP00000028010

UniGene: Mm.2900

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Fmo3 Antibody

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