fnr Antibody

Code CSB-PA359284XA01ENV
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) fnr Polyclonal antibody
Uniprot No.
Target Names
fnr
Alternative Names
fnr antibody; nirR antibody; b1334 antibody; JW1328Fumarate and nitrate reduction regulatory protein antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12)
Immunogen
Recombinant Escherichia coli (strain K12) fnr protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration.
Gene References into Functions
  1. Elevated expression of GlpT and UhpT via FNR activation contributes to increased fosfomycin susceptibility in Escherichia coli under anaerobic conditions. PMID: 26248376
  2. These results demonstrate that FNR is a key global regulator of uropathogenic Escherichia coli virulence and controls expression of important virulence factors that contribute to uropathogenic Escherichia coli pathogenicity. PMID: 25245807
  3. DNA-bound FNR reacts more rapidly with O2 than FNR free in solution, implying that transcriptionally active FNR is the preferred target for reaction with O2. PMID: 25019503
  4. FNR bound some promoters without regulating expression presumably requiring changes in activity of condition-specific transcription factors. Such combinatorial regulation may allow Escherichia coli to respond rapidly to environmental changes PMID: 23818864
  5. oxygen stable FNR variants were obtained. PMID: 22326866
  6. The authors characterized the steady-state behavior of the FNR system by determining its sensitivity to changes in parameter values and its response to changes in the concentration of iron-sulfur cluster assembly proteins and the protease ClpXP. PMID: 20156450
  7. regulates aerobic transcription of anaerobically induced focA-pfL operon PMID: 16448504
  8. the reaction between O2 and the [4Fe-4S]2+ cluster of FNR does not require sulfide oxidation and hence must entail iron oxidation PMID: 16717103
  9. Measurement of binding sites of the global transcription regulator protein, FNR, across the entire Escherichia coli chromosome. PMID: 17164287
  10. a one electron activation of the [4Fe-4S]2+ cluster, coupled to catalytic recycling of the resulting superoxide ion back to oxygen, provides a means of amplifying the sensitivity of [4Fe-4S] FNR to its signal molecule PMID: 17267605
  11. Here both FNR and OxyR are shown to regulate expression of the E. coli yhjA gene. PMID: 17464064
  12. The results demonstrate that the major form of FNR in aerobically growing E. coli is apoFNR lacking disulfides. [apoFNR] PMID: 18055593
  13. may have significance for the in vivo FNR cluster conversion reaction in the cell cytoplasm PMID: 18186637
  14. Mapping the ydhY-T transcript confirmed that the ydhY-T genes are transcribed from an FNR-dependent class II promoter and showed that the FNR site is centred at -42.5. PMID: 18227264
  15. Removal of N-terminal amino acid residues 2 to 16 and 2 to 17 from the global transcription factor FNR increases its activity under aerobic conditions. PMID: 18931113
  16. Results suggest that the Fnr and Crp proteins may act synergistically to enhance NapABC synthesis during growth with poor carbon sources to help obtain energy from low levels of nitrate. PMID: 19060147

Show More

Hide All

Subcellular Location
Cytoplasm.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1