Recombinant Escherichia coli Fumarate and nitrate reduction regulatory protein (fnr)

1. Elevated expression of GlpT and UhpT via FNR activation contributes to increased fosfomycin susceptibility in Escherichia coli under anaerobic conditions. PMID: 26248376
2. These results demonstrate that FNR is a key global regulator of uropathogenic Escherichia coli virulence and controls expression of important virulence factors that contribute to uropathogenic Escherichia coli pathogenicity. PMID: 25245807
3. DNA-bound FNR reacts more rapidly with O2 than FNR free in solution, implying that transcriptionally active FNR is the preferred target for reaction with O2. PMID: 25019503
4. FNR bound some promoters without regulating expression presumably requiring changes in activity of condition-specific transcription factors. Such combinatorial regulation may allow Escherichia coli to respond rapidly to environmental changes PMID: 23818864
5. oxygen stable FNR variants were obtained. PMID: 22326866
6. The authors characterized the steady-state behavior of the FNR system by determining its sensitivity to changes in parameter values and its response to changes in the concentration of iron-sulfur cluster assembly proteins and the protease ClpXP. PMID: 20156450
7. regulates aerobic transcription of anaerobically induced focA-pfL operon PMID: 16448504
8. the reaction between O2 and the [4Fe-4S]2+ cluster of FNR does not require sulfide oxidation and hence must entail iron oxidation PMID: 16717103
9. Measurement of binding sites of the global transcription regulator protein, FNR, across the entire Escherichia coli chromosome. PMID: 17164287
10. a one electron activation of the [4Fe-4S]2+ cluster, coupled to catalytic recycling of the resulting superoxide ion back to oxygen, provides a means of amplifying the sensitivity of [4Fe-4S] FNR to its signal molecule PMID: 17267605
11. Here both FNR and OxyR are shown to regulate expression of the E. coli yhjA gene. PMID: 17464064
12. The results demonstrate that the major form of FNR in aerobically growing E. coli is apoFNR lacking disulfides. [apoFNR] PMID: 18055593
13. may have significance for the in vivo FNR cluster conversion reaction in the cell cytoplasm PMID: 18186637
14. Mapping the ydhY-T transcript confirmed that the ydhY-T genes are transcribed from an FNR-dependent class II promoter and showed that the FNR site is centred at -42.5. PMID: 18227264
15. Removal of N-terminal amino acid residues 2 to 16 and 2 to 17 from the global transcription factor FNR increases its activity under aerobic conditions. PMID: 18931113
16. Results suggest that the Fnr and Crp proteins may act synergistically to enhance NapABC synthesis during growth with poor carbon sources to help obtain energy from low levels of nitrate. PMID: 19060147

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KEGG: ecj:JW1328

STRING: 316385.ECDH10B_1454