fz Antibody

1. The stabilizing function of Prickle on Frizzled requires Prickle activity in neighboring cells. Conversely, Prickle in the same cell has a destabilizing effect on Frizzled. PMID: 28918952
2. instructive input of Frizzled-Planar cell polarity (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings, is reported. PMID: 27021213
3. Studies indicate that Frizzled (Fz) is constitutively ubiquitinated and internalized to the early endosome. PMID: 22825661
4. We found no evidence for an essential requirement of the Fz C-terminal tail downstream of the KTxxxW motif in planar polarity and canonical Wnt signaling. PMID: 23023003
5. Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity. PMID: 22949620
6. Frazzled is expressed and cell autonomously required in R8 photoreceptors for directing their axons to the medulla-neuropil layer M3. PMID: 22794263
7. Frizzled and Dishevelled are enriched at distal sides of each cell and hence localize at the interface with ligand-expressing cells in the non-responding cells. PMID: 22736244
8. Correct specification of a single R3 cell per ommatidium is essential for the normal interpretation of the Fz-mediated polarity signal. PMID: 9651479
9. Frizzled is involved in positional information signaling during development in the coordinated orientation of ommatidia in the Drosophila eye. PMID: 11893338
10. Function is dependent on inturned protein and on fuzzy protein. PMID: 11973308
11. Pk causes fz to have an asymmetric localization in the cytoplasm of Drosophila. PMID: 12015986
12. role of dachsous and fat acting upstream of frizzled in regulation of ommatidia orientation PMID: 12062069
13. Genetic interactions and epistasis analysis suggest that frizzled, dishevelled,and fat act together in the long-range propagation of polarity signals in the eye and wing. PMID: 12479810
14. Data show that Dishevelled (Dvl) binding peptides of Frizzled inhibited canonical Wnt signaling and blocked Wnt-induced secondary axis formation in a dose-dependent manner, but did not block noncanonical Wnt signaling. PMID: 14636582
15. We propose a model whereby the dPatj/aPKC complex regulates PCP by inhibiting Fz1 in cells where it should not be active. PMID: 15907474
16. Frizzled signalling is promoted by binding of Diego with Dishevelled. PMID: 15937478
17. Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism. PMID: 16085697
18. Fz activates signaling in two steps: Fz uses its cysteine-rich domain to capture Wingless, and once bound Wg interacts with the membrane portion of the receptor to initiate signaling. PMID: 16163385
19. wing cells acquire planar polarity along the proximal-distal axis, and Frizzled localizes at the distal side PMID: 16459300
20. Drosophila planar cell polarity is under the hierarchical control of Frizzled (Fz)-a serpentine receptor (that also functions in the Wnt signaling pathway) [review] PMID: 17102631
21. examined the role of a Dsh-binding PCP molecule, Diego (Dgo), in both Wnt-Fz/beta-catenin and Fz/PCP signaling PMID: 18065209

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KEGG: dme:Dmel_CG17697

STRING: 7227.FBpp0303135

UniGene: Dm.1456